Joy（卡梅隆•迪亚茨 Cameron Diaz 饰）处处以男友Mason为中心而丧失了自我。但Mason反而对此厌倦向Joy提出分手。Jack（阿什顿•库彻 Ashton Kutcher 饰）在父亲的家具工厂上班但并不努力，对此失望的父亲一怒之下解雇了他。两个失意的人，在各自好友Tipper（蕾克•贝尔 Lake Bell 饰）和Hate（罗伯•考德瑞 Rob Corddry 饰）的劝说下前往拉斯维加斯度假。灯红酒绿，两个心灵受伤的人敞开了心胸，度过了疯狂而美好的夜晚。早晨醒来发现结了婚，而Joy出钱Jack出力的一次赌博竟赢得了300万美元的大奖，都想独吞奖金的两人找来了法官。法官为惩罚两人对婚姻的儿戏，判决冻结奖金6个月。互不相让的两人在各自好友的建议下决定“击垮”对方，逼对方先提出离婚，自己可以独吞奖金。于是，一场场争锋相对却妙趣横生的较量随之展开......
Adult brothers Mark and Colin Pollock still live with their parents Frank and Mavis Pollock in a small apartment in the projects of London's east end in what is a collective depressed and unhappy existence. The three men of the household are all on the dole, each doing little to find gainful employment. Between the brothers, Mark is the smart aleck, who calls his parents by their given names to irk them, and who hangs out with a bunch of hooligans as he refers to himself and his friends, such as a skinhead named Coxy. Although never medically diagnosed as such, Colin is seemingly emotionally slow. Colin likes to hang out with Mark and his friends in his want to be accepted, especially as Mark tells him that a neighborhood girl named Hayley is interested him. The family rarely socializes with Mavis' sister and brother-in-law, Barbara and John, who live a middle to upper middle class and seemingly perfect existence in the suburbs of Chigwell. Although not telling them to their face, John dislikes his relations by marriage, believing especially Mark to be brash and trashy. A unilateral act by Barbara leads to many issues within the extended family coming to the surface, most specifically the true happiness of the marriage between Barbara and John, and what Colin is truly looking for to be happy in life.
A deadbeat dad, an insurance scammer, and an MMA coach must avenge their Kung Fu master's death but first - they need to call in sick at their 9-to-5's.
医学院新生爱莉逊•布兰德曼（Corri English 饰）入学不久便迎来了从医道路上的最大挑战——人体解剖课程。她和同学布兰（Scot Davis 饰）、卡洛斯（Joshua Alba 饰）、里克（Jay Jablonski 饰）分配到的是一具女性的尸体，然而这具尸体却令他们产生一种说不出的奇怪感受。爱莉逊将这一情况报告给当值的布莱克威尔教授（Derrick O'Connor 饰），反而遭到一阵奚落。
不久，接触过这具尸体的人接连死亡，死状恐怖。爱莉逊开始有意识地探究这具女尸背后的秘密……
一次偶然中，雷吉纳（桑迪·牛顿 Thandie Newton 饰）邂逅了名为查理（斯蒂芬·迪兰 Stephen Dillane 饰）的男子，两人很快就坠入了爱河，并且决定携手步入婚姻的殿堂。可新婚的甜蜜劲过去之后，雷吉纳发现查理是一个背负了许多秘密的男人，这个整天躺在自己身边的男人，自己或许对他毫不了解。于是，雷吉纳决定去旅行散心，顺便思考一下自己的这段草率的婚姻。 可是，当雷吉纳返回巴黎住所后，等待着她的并非查理，而是空空如也的房间，以及自称是查理同伴的三个陌生人。三人告诉雷吉纳，查理手上拿着本该和他们平分的一大笔钱，如今查理失踪了，身为他的妻子，雷吉纳有责任供出这笔钱的下落。
由于在纽约自然历史博物馆担任警卫有出色表现，拉瑞（本·斯蒂勒 Ben Stiller 饰）出任某家电小公司的CEO，而且还在电视上接受了著名脱口秀主持人的访谈，儿子对他仰慕，爱情如影随形，一派春风得意的样子。不过，好景不长，当他故地重游，却意外发现馆长已经因为更新展览并准备把过时的展品挪到华盛顿的史密森博物馆继续展出。这让拉瑞感到有些气愤，他觉得自己有责任重振博物馆之雄风，于是他决定留下来再做一晚警卫，以唤起那些老朋友的共同努力。事实上，在搞定了罗斯福（罗宾·威廉斯 Robin Williams 饰）、林肯、拿破仑、伊凡雷帝和阿尔•卡邦等人之后，他遭遇了一个劲敌——邪恶的古埃及法老的卡门拉，二人在夜晚再度上演了博物馆的惊魂对决……
